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A 2015 rabbit osteoarthritis model found that intra-articular injection of AOD-9604, particularly combined with hyaluronic acid, improved cartilage integrity and reduced joint degradation

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Unlike GLP-1 agonists that reduce appetite or growth hormone peptides that stimulate lipolysis, the compound addresses fat metabolism at the enzymatic level: it removes the molecular governor that locks adipocytes into a low-energy-expenditure state, potentially restoring normal metabolic function in fat tissue where NNMT is overexpressed

10.1007/s11596-020-2260-7 [DOI] [PubMed] 12.Carmel R (2008) How I treat cobalamin (vitamin B12) deficiency